GasMaskie
"Wait and Hope"
I started with the Fate route and it left me with a lot of questions, which helped me get deeper into the franchise. I can see why Fate/Zero can be a good starting point for a beginner, but since it's a prequel, I think it still takes some things away from the experience of the other routes. I haven't read many of the mana adaptions, but I'll likely dive into them soon.
I had a theory that one of their kids would be named Ringo, since apples are red in color and it takes the "go" from Akago's name.
Genes don't seem to matter much in anime, but it makes for some interesting designs.
There's barely any manga adaptations. With side materials, the Fate/Apocrypha and Fate/strange fake manga are still ongoing. I remember one being made for the Fate route, not sure if they also did UBW and HF. You're shit out of luck for F/HA, the only way you'll get the story is to play through it, though it's pretty simple and could easily be summarized. I feel like starting with Fate/Zero eliminates some of the mystery of what lead to the events of F/SN. Oh, and if @Pequeno Burraidh ends up depressed after Fate/Zero, go watch Carnival Phantasm for the Fate parts. Though it might tempt you into Tsukihime since those parts are equally fun.